PATHOLOGIES OF THE LUNGS
Unraveling the Mysteries of Tuberculosis: History, Symptoms, and Prevention
Tuberculosis (TB) is an infectious disease that has plagued humanity for centuries. It is caused by the bacteria Mycobacterium tuberculosis and primarily affects the lungs. Here, we will delve into the history, symptoms, and prevention of tuberculosis, shedding light on this ancient disease.
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History of Tuberculosis: Tuberculosis has a long and storied history, dating back thousands of years. It has been found in the remains of Egyptian mummies and has been mentioned in ancient texts. In the 19th and early 20th centuries, tuberculosis was a major public health crisis, causing widespread illness and death. It was known as the "white plague" due to the pale appearance of those affected.
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Symptoms of Tuberculosis: Tuberculosis can present with a variety of symptoms, some of which may be mistaken for other respiratory illnesses.
Common symptoms include persistent coughing, chest pain, fatigue, weight loss, night sweats, and coughing up blood. If you experience any of these symptoms, it is important to seek medical attention promptly.
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Pathology of Tuberculosis: Histopathologically, tuberculosis typically presents as granulomatous inflammation characterized by the formation of epithelioid cell granulomas, which may undergo caseation necrosis. These granulomas often contain central areas of necrosis surrounded by lymphocytes, plasma cells, and multinucleated giant cells, reflecting the host's attempt to contain the mycobacterial infection.
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Prevention of Tuberculosis: Preventing tuberculosis involves a multi-faceted approach. Here are some key tips to reduce your risk of contracting and spreading the disease:
1. Vaccination: The Bacillus Calmette-Guérin (BCG) vaccine is available in some countries and can provide protection against severe forms of tuberculosis, particularly in children. Consult with your healthcare provider to determine if the BCG vaccine is recommended for you.
2. Good hygiene practices: Practicing good hygiene, such as regular handwashing, can help prevent the spread of tuberculosis. Cover your mouth and nose with a tissue or your elbow when coughing or sneezing to prevent the bacteria from spreading.
3. Avoid close contact with infected individuals: Tuberculosis is primarily spread through the air when an infected person coughs or sneezes. Avoid close contact with individuals who have active tuberculosis to reduce your risk of exposure.
4. Early detection and treatment: If you suspect you may have tuberculosis or have been in contact with someone who has the disease, seek medical attention promptly. Early detection and treatment can help prevent the spread of tuberculosis and improve outcomes.
In conclusion, tuberculosis is a disease with a rich history and significant impact on public health. By understanding its history, recognizing its symptoms, and taking preventive measures, we can work towards reducing the burden of tuberculosis and protecting our lungs. Stay informed, stay vigilant, and prioritize your respiratory health.

Mycobacterium Tuberculosis. Photo Credit: Biodefense.

Tuberculosis Ward. Photo Credit: PBS

Histological views of tuberculous nodule. At the center is a granuloma comprising caseous necrosis surrounded by epithelioid cells including Langhans-type giant cells (arrow). Photo Credit: Pathology Core Pictures.
Test Your Knowledge
1) What bacteria is responsible for causing tuberculosis?
A) Mycobacterium tuberculosis
B) Streptococcus pneumoniae
C) Haemophilus influenzae
D) Staphylococcus aureus
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2) Which of the following is NOT a common symptom of tuberculosis?
A) Persistent coughing
B) Chest pain
C) Fever
D) Skin rash
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3) What histopathological feature characterizes tuberculosis?
A) Suppurative inflammation
B) Fibrinous exudate
C) Granulomatous inflammation with caseation necrosis
D) Eosinophilic infiltrate
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4) What is a key preventive measure against tuberculosis?
A) Consuming raw garlic
B) Wearing a face mask outdoors
C) Regular handwashing
D) Avoiding vaccination
5) What is the primary mode of transmission for tuberculosis?
A) Ingestion of contaminated food
B) Inhalation of respiratory droplets containing the bacteria
C) Blood transfusion
D) Sexual contact